Water → Acifluorfen-methyl

HRID 1075317

反応式

HRID 1075317 の反応式
[F:1][C:2]([F:24])([F:23])[C:3]1[CH:22]=[CH:21][C:6]([O:7][C:8]2[CH:9]=[CH:10][C:11]([N+:18]([O-:20])=[O:19])=[C:12]([CH:17]=2)[C:13]([O:15][CH3:16])=[O:14])=[CH:5][CH:4]=1.[Cl:25]Cl.O>CCOCC>[Cl:25][C:5]1[CH:4]=[C:3]([C:2]([F:23])([F:24])[F:1])[CH:22]=[CH:21][C:6]=1[O:7][C:8]1[CH:9]=[CH:10][C:11]([N+:18]([O-:20])=[O:19])=[C:12]([CH:17]=1)[C:13]([O:15][CH3:16])=[O:14]

参加物

5

反応物 3

HCID 962WaterHCID 24526ChlorineHCID 13209694Methyl 2-nitro-5-[4-(trifluoromethyl)phenoxy]benzoate

生成物 1

HCID 91642Acifluorfen-methyl

試薬・触媒・溶媒 1

HCID 3283Diethyl Ether溶媒

実験手順

Methyl 5-(4-trifluoromethylphenoxy)-2-nitrobenzoate is stirred with a catalytic amount of ferric chloride. The reaction mixture was heated to 70° C. under a continuous stream of chlorine gas. After 2.5 hours, the mixture was taken up in ether, shaken with water and the organic phase was dried over MgSO4. The ether was evaporated to afford methyl 5-(2-chloro-4-trifluoromethylphenoxy)-2-nitrobenzoate. NMR (CDCl3)δ8.2-7 (m,6) 4.0 (2,3). TLC (40% ether/hexane) Rf ≈.4.

後処理

  1. dry with materialthe organic phase was dried over MgSO4
  2. customThe ether was evaporated

出典と根拠

ORDレコード
ord-c85e0659d8554c0b9334c310b60f0b5a
出典データセット
uspto-grants-1983_07
特許番号
US04395570

関連ノート

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