Hydrogen Bromide → 1-Bromocyclopentane-1-carboxylic acid

温度

60 °C

20 g (0.176 mol) of cyclopentaencarboxylic acid are mixed with red phosphorus (2.5 g). 17.9 ml (0.352 mol) of bromine are added dropwise thereto over the course of 2 hours; thereupon, a vigorous reaction is observed, with liberation of hydrogen bromide. The reaction contents are then stirred for 3 hours at 60°C. The oil, which shows a heavy dark coloration, is cooled and poured into water and the resulting reaction mixture is extracted three times with ether. The collected ether phases are washed with water and dried. After distilling off the ether, the oily residue is distilled in a high vacuum.

1. customover the course of 2 hours
2. customthereupon, a vigorous reaction
3. customThe reaction contents
4. temperatureis cooled
5. customthe resulting reaction mixture
6. extractionis extracted three times with ether
7. washThe collected ether phases are washed with water
8. customdried
9. distillationAfter distilling off the ether
10. distillationthe oily residue is distilled in a high vacuum

ORDレコード

ord-654a526be28a4576b8180e27880c6919

出典データセット

uspto-grants-1976_05

DOI

10.6084/m9.figshare.5104873.v1

特許番号

US03954730