Pyrrolidine → 2-Aminopyrazine-3-carboxylic acid pyrrolidide

HRID 1075767ノート

反応式

HRID 1075767 の反応式
[NH2:1][C:2]1[C:7]([C:8]([O:10]C)=O)=[N:6][CH:5]=[CH:4][N:3]=1.[NH:12]1[CH2:16][CH2:15][CH2:14][CH2:13]1>CO>[NH2:1][C:2]1[C:7]([C:8]([N:12]2[CH2:16][CH2:15][CH2:14][CH2:13]2)=[O:10])=[N:6][CH:5]=[CH:4][N:3]=1

参加物

4

反応物 2

HCID 31268PyrrolidineHCID 72669Methyl 3-aminopyrazinecarboxylate

生成物 1

HCID 539368772-Aminopyrazine-3-carboxylic acid pyrrolidide

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

A solution of 10 g. (0.065 mol) of methyl 2-aminopyrazine-3-carboxylate in 100 ml. of methanol and 25 ml. of pyrrolidine was refluxed for 18 hours. The residue obtained after evaporation under reduced pressure was triturated with ether to yield 8.8 g. (70%) of the above-named product as yellow crystals, with m.p. 100°-105°. A second crop of 2.3 g. (18%) with m.p. 95°-105° was obtained from the mother liquors. The analytical sample was recrystallized from 2-propanol. The pale yellow prisms had a melting point of 104°-106°.

後処理

  1. customThe residue obtained
  2. customafter evaporation under reduced pressure
  3. customwas triturated with ether
  4. customto yield 8.8 g
  5. custom(18%) with m.p. 95°-105° was obtained from the mother liquors
  6. customThe analytical sample was recrystallized from 2-propanol

出典と根拠

ORDレコード
ord-67a7a9ff92cf4ffa887a17b8c8ce24d9
出典データセット
uspto-grants-1976_05
特許番号
US03954753

反応ノート

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