Tetrahydrofuran → (3-Amino-pyrazin-2-YL)-phenyl-methanone

HRID 1075769ノート

反応式

HRID 1075769 の反応式
[NH2:1][C:2]1[C:7]([C:8](N2CCCC2)=[O:9])=[N:6][CH:5]=[CH:4][N:3]=1.[C:15]1([Mg]Br)[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1.O1CCCC1>O>[NH2:1][C:2]1[C:7]([C:8](=[O:9])[C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)=[N:6][CH:5]=[CH:4][N:3]=1

参加物

5

反応物 3

HCID 8028TetrahydrofuranHCID 539368772-Aminopyrazine-3-carboxylic acid pyrrolidideHCID 178418255HCID 178418255、化合物

生成物 1

HCID 10899618(3-Amino-pyrazin-2-YL)-phenyl-methanone

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

2-Aminopyrazine-3-carboxylic acid pyrrolidide (63.4 g. or 0.33 mol) was added to a solution of freshly prepared phenylmagnesium bromide (305 g.) in 1 l. of tetrahydrofuran while the temperature was kept at 20°-30° by cooling with an ice bath. After stirring at room temperature for 2 hours, the mixture was hydrolyzed by addition of 2 l. of water. The aqueous layer was extracted twice with 500 ml. of methylene chloride. The extracts were combined with the organic layer, dried over sodium sulfate and evaporated. The brown residue was slurried with ether to yield 37.5 g. (56%) of yellow crystals of the above-named product.

後処理

  1. customwas kept at 20°-30°
  2. temperatureby cooling with an ice bath
  3. additionthe mixture was hydrolyzed by addition of 2 l
  4. extractionThe aqueous layer was extracted twice with 500 ml
  5. dry with materialdried over sodium sulfate
  6. customevaporated
  7. customto yield 37.5 g

出典と根拠

ORDレコード
ord-b02e473201f7415486d64d8269502233
出典データセット
uspto-grants-1976_05
特許番号
US03954753

反応ノート

読み込み中…