6-Methyluracil → 5-Fluoro-6-methylpyrimidine-2,4-diol

HRID 1075784ノート

反応式

HRID 1075784 の反応式
[CH3:1][C:2]1[NH:7][C:6](=[O:8])[NH:5][C:4](=[O:9])[CH:3]=1.[F:10]F>O>[F:10][C:3]1[C:4](=[O:9])[NH:5][C:6](=[O:8])[NH:7][C:2]=1[CH3:1]

参加物

4

反応物 2

HCID 122836-MethyluracilHCID 24524Fluorine2 回

生成物 1

HCID 2338935-Fluoro-6-methylpyrimidine-2,4-diol

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

The preceding example was substantially repeated but at a lower reaction temperature. A suspension of 6-methyl uracil (4.00g) in water (30 ml) was maintained at 0°-10°C and fluorinated with a stream of fluorine and nitrogen, present in equal volumes, until fluorine was detected at the reactor outlet. The reaction mixture was allowed to stand for two days at room temperature and 1.05g of crystals were collected and found to have a different IR spectrum than the starting material. A DSC analysis showed 2 transitions at 313°C and 318°C followed by apparent decomposition. The structure of the product was identified as 5-fluoro-6-methyl uracil by NMR analysis.

後処理

  1. temperaturewas maintained at 0°-10°C
  2. custom1.05g of crystals were collected
  3. customat 313°C
  4. custom318°C

出典と根拠

ORDレコード
ord-e0e30c37034847b09d50279a7227833d
出典データセット
uspto-grants-1976_05
特許番号
US03954758

反応ノート

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