Epichlorohydrin → 1,2-Epoxy-3-[3-(2-pyridylmethyl)phenoxy]propane

HRID 1075855ノート

反応式

HRID 1075855 の反応式
[CH2:1]([CH:3]1[O:5][CH2:4]1)Cl.[N:6]1[CH:11]=[CH:10][CH:9]=[CH:8][C:7]=1[CH2:12][C:13]1[CH:14]=[C:15]([OH:19])[CH:16]=[CH:17][CH:18]=1.[OH-].[Na+]>CO>[O:5]1[CH:3]([CH2:1][O:19][C:15]2[CH:16]=[CH:17][CH:18]=[C:13]([CH2:12][C:7]3[CH:8]=[CH:9][CH:10]=[CH:11][N:6]=3)[CH:14]=2)[CH2:4]1

参加物

5

反応物 3

HCID 7835EpichlorohydrinHCID 14798Sodium HydroxideHCID 215413183-[(Pyridin-2-yl)methyl]phenol

生成物 1

HCID 129198521,2-Epoxy-3-[3-(2-pyridylmethyl)phenoxy]propane収率 62.2%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

反応条件

温度
50 °C

実験手順

19 g of epichlorohydrin is added to a mixture of 18.5 g of 3-(2-pyridylmethyl)phenol, 4.2 g of sodium hydroxide and 200 ml of methanol, and the resulting mixture is stirred at about 50°C for 3 hours. The methanol is then removed, water is added to the residue, and the aqueous solution is extracted with 200 ml of benzene. The benzene layer is washed with 5% sodium hydroxide and with water, and dried over anhydrous magnesium sulfate. The benzene is removed to give 15.0 g of 1,2-epoxy-3-[3-(2-pyridylmethyl)-phenoxy] propane as oil.

後処理

  1. customThe methanol is then removed
  2. additionwater is added to the residue
  3. extractionthe aqueous solution is extracted with 200 ml of benzene
  4. washThe benzene layer is washed with 5% sodium hydroxide and with water
  5. dry with materialdried over anhydrous magnesium sulfate
  6. customThe benzene is removed

出典と根拠

ORDレコード
ord-96f42c65db9e4ce5a0987d605fb71031
出典データセット
uspto-grants-1976_05
特許番号
US03954776

反応ノート

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