Ethanol → 10,11-Dihydro-3-methoxy-8-(methylthio)-dibenzo thiepin-10-ol

HRID 1075873ノート

反応式

HRID 1075873 の反応式
[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]2[CH2:12][C:11](=O)[C:10]3[CH:14]=[C:15]([S:18][CH3:19])[CH:16]=[CH:17][C:9]=3[S:8][C:7]=2[CH:20]=1.C([OH:23])C.[BH4-].[Na+]>O>[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]2[C:12]3[CH2:11][CH:10]([OH:23])[CH:14]=[C:15]([S:18][CH3:19])[C:16]=3[CH:17]=[CH:9][S:8][C:7]=2[CH:20]=1

参加物

5

反応物 3

HCID 702EthanolHCID 4311764Sodium borohydrideHCID 128221953-methoxy-8-methylthio-dibenzo[b,f]thiepin-10(11H)-one

生成物 1

HCID 2154119710,11-Dihydro-3-methoxy-8-(methylthio)-dibenzo thiepin-10-ol

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

17.8 G. of 3-methoxy-8-(methylthio)-dibenzo[b,f]thiepin-10(11H)-one is suspended in 150 ml. of ethanol and reacted with 38 g. of sodium borohydride. The reaction mixture is stirred for 90 minutes, and subsequently treated with water and extracted with ether. The organic phase is washed with water, dried over magnesium sulfate and evaporated, whereby there is obtained 10,11-dihydro-3-methoxy-8-(methylthio)-dibenzo[d,f]thiepin-10-ol having a melting point of 122°-124°.

後処理

  1. extractionextracted with ether
  2. washThe organic phase is washed with water
  3. dry with materialdried over magnesium sulfate
  4. customevaporated

出典と根拠

ORDレコード
ord-bee840270add48898f1237dbb4de0ce9
出典データセット
uspto-grants-1976_05
特許番号
US03954764

反応ノート

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