Hydrochloric Acid → 1-Methyl-2-nitro-1H-imidazole-5-methanol

HRID 1075967

反応式

HRID 1075967 の反応式
[CH3:1][N:2]1[C:6]([CH:7]=[O:8])=[CH:5][N:4]=[C:3]1[N+:9]([O-:11])=[O:10].[BH4-].[Na+].Cl>C(O)C>[CH3:1][N:2]1[C:6]([CH2:7][OH:8])=[CH:5][N:4]=[C:3]1[N+:9]([O-:11])=[O:10]

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 1003901-Methyl-2-nitro-1H-imidazole-5-carboxaldehydeHCID 4311764Sodium borohydride2 回

生成物 1

HCID 702921-Methyl-2-nitro-1H-imidazole-5-methanol

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒2 回

反応条件

温度
0 °C

実験手順

To a solution of 1.55 g. of 1-methyl-2-nitro-5-imidazolecarboxaldehyde in 200 ml. of ethanol, a solution of 1.9 g. of NaBH4 in 150 ml. of ethanol is added at about -4° C. After stirring for 15 minutes at 0° C., the excess of NaBH4 is decomposed with 10% hydrochloric acid and the reaction mixture is filtered. the residue, which is obtained by evaporation of the filtrate, is crystallized from acetone and yield 1 g. of the title product which melts at 142°-144° C.

後処理

  1. filtrationthe reaction mixture is filtered
  2. customthe residue, which is obtained by evaporation of the filtrate
  3. customis crystallized from acetone and yield 1 g

出典と根拠

ORDレコード
ord-2ee062bf2eb644f78f5f014167135e51
出典データセット
uspto-grants-1976_05
特許番号
US03954789

関連ノート

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