1-Methyl-2-nitro-1H-imidazole-5-methanol → 1-Methyl-2-nitro-1H-imidazole-5-carboxaldehyde

HRID 1075969ノート

反応式

HRID 1075969 の反応式
[CH3:1][N:2]1[C:6]([CH2:7][OH:8])=[CH:5][N:4]=[C:3]1[N+:9]([O-:11])=[O:10]>O=[Mn]=O.C1C=CC=CC=1>[CH3:1][N:2]1[C:6]([CH:7]=[O:8])=[CH:5][N:4]=[C:3]1[N+:9]([O-:11])=[O:10]

参加物

4

反応物 1

HCID 702921-Methyl-2-nitro-1H-imidazole-5-methanol

生成物 1

HCID 1003901-Methyl-2-nitro-1H-imidazole-5-carboxaldehyde収率 40.5%

試薬・触媒・溶媒 2

HCID 14801Manganese dioxide触媒HCID 241Benzene溶媒

実験手順

To a solution of 0.15 g. of 1-methyl-2-nitro-5-hydroxymethylimidazole in 20 ml. of benzene, 0.33 g. of MnO2 is added and the reaction mixture is heated on the steambath for 2 hours. After filtration and evaporation to dryness under vacuum, the crude product is crystallized from ethyl acetate and 0.060 g. (40.5%) of 1-methyl-2-nitro-5-imidazolaldehyde is obtained.

後処理

  1. temperaturethe reaction mixture is heated on the steambath for 2 hours
  2. filtrationAfter filtration and evaporation to dryness under vacuum
  3. customthe crude product is crystallized from ethyl acetate and 0.060 g

出典と根拠

ORDレコード
ord-46bcf94c66ce401ebe1aefe460d1fb12
出典データセット
uspto-grants-1976_05
特許番号
US03954789

反応ノート

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