Formic Acid → HCID 54073686、化合物

HRID 1076291

反応式

HRID 1076291 の反応式
[OH:1][C@H:2]1[CH2:19][C@@:17]2([CH3:18])[C@@H:13]([CH2:14][CH2:15][C:16]2=[O:20])[C@H:12]2[C@H:3]1[C@:4]1([CH3:22])[C:9]([CH2:10][CH2:11]2)=[CH:8][C:7](=[O:21])[CH2:6][CH2:5]1.[CH:23](O)=[O:24]>Cl(O)(=O)(=O)=O>[CH:23]([O:1][C@H:2]1[CH2:19][C@@:17]2([CH3:18])[C@@H:13]([CH2:14][CH2:15][C:16]2=[O:20])[C@H:12]2[C@H:3]1[C@:4]1([CH3:22])[C:9]([CH2:10][CH2:11]2)=[CH:8][C:7](=[O:21])[CH2:6][CH2:5]1)=[O:24]

参加物

4

反応物 2

HCID 284Formic AcidHCID 9414111beta-Hydroxyandrost-4-ene-3,17-dione

生成物 1

HCID 54073686HCID 54073686、化合物

試薬・触媒・溶媒 1

HCID 24247Perchloric Acid溶媒

実験手順

The starting 11β-formyloxy-androst-4-ene-3,17-dione was prepared from 11β-hydroxy-androst-4-ene-3,17-dione by dissolving the latter in excess formic acid in the presence of a catalytic amount of perchloric acid and, after 20 hours at room temperature, pouring the reaction mixture on ice, extracting with methylene chloride and evaporating. There was obtained a product melting at 139°-139.5° (crystallized from ethyl acetate), [α]D25 = 188° (dioxane).

後処理

  1. additionpouring the reaction mixture on ice
  2. extractionextracting with methylene chloride
  3. customevaporating

出典と根拠

ORDレコード
ord-eaf3f77e037045739706134295f6bafd
出典データセット
uspto-grants-1976_05
特許番号
US03956316

関連ノート

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