Methyl iodide → 3-Methoxy-1-methylpyridin-2-one

HRID 1076826ノート

反応式

HRID 1076826 の反応式
[CH3:1][O:2][C:3]1[C:4](=[O:9])[NH:5][CH:6]=[CH:7][CH:8]=1.[OH-].[K+].[CH3:12]I>CO>[CH3:12][N:5]1[CH:6]=[CH:7][CH:8]=[C:3]([O:2][CH3:1])[C:4]1=[O:9]

参加物

5

反応物 3

HCID 6328Methyl iodideHCID 14797Potassium HydroxideHCID 887313-Methoxy-2-pyridone

生成物 1

HCID 5870243-Methoxy-1-methylpyridin-2-one

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

A mixture of 3-methoxy-2(1H)-pyridone (25 g., 0.2 moles), potassium hydroxide (16 g., 0.24 moles) and methyl iodide (45.4 g., 0.32 moles) in 400 ml. methanol is heated at reflux for 5 hours. The methanol is removed under reduced pressure leaving a solid redidue which is extracted with methylene chloride. The methylene chloride extracts are washed with water, a saturated salt solution, and dried over sodium sulfate. Evaporation of the dried extracts, under reduced pressure, affords 1-methyl-3-methoxy-2(1H)-pyridone as a colorless oil which solidifies on standing (26.2 g., 94%). The pyridone is very hygroscopic and rapidly liquifies on exposure to air.

後処理

  1. temperatureat reflux for 5 hours
  2. customThe methanol is removed under reduced pressure
  3. customleaving a solid redidue which
  4. extractionis extracted with methylene chloride
  5. washThe methylene chloride extracts are washed with water
  6. dry with materiala saturated salt solution, and dried over sodium sulfate
  7. customEvaporation of the dried extracts

出典と根拠

ORDレコード
ord-14fbee2fa7ed4ca0bea4dcb2924b3026
出典データセット
uspto-grants-1976_05
特許番号
US03957997

反応ノート

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