3-Nitroaniline → 3-chloro-N-(3-nitrophenyl)propanamide

HRID 1076933ノート

反応式

HRID 1076933 の反応式
[N+:1]([C:4]1[CH:5]=[C:6]([CH:8]=[CH:9][CH:10]=1)[NH2:7])([O-:3])=[O:2].[Cl:11][CH2:12][CH2:13][C:14](Cl)=[O:15]>C1C=CC=CC=1>[N+:1]([C:4]1[CH:5]=[C:6]([NH:7][C:14](=[O:15])[CH2:13][CH2:12][Cl:11])[CH:8]=[CH:9][CH:10]=1)([O-:3])=[O:2]

参加物

4

反応物 2

HCID 74233-NitroanilineHCID 693643-Chloropropionyl chloride

生成物 1

HCID 34652363-chloro-N-(3-nitrophenyl)propanamide

試薬・触媒・溶媒 1

HCID 241Benzene溶媒

実験手順

3-Nitroaniline (0.3 moles), β-chloropropionyl chloride (0.35 mole) and benzene (100 ml) are charged into a glass reaction vessel equipped with a mechanical stirrer, thermometer and reflux condenser. The reaction mixture is heated at reflux with stirring for a period of about 4 hours. After this time the reaction mixture is cooled to room temperature and is washed with dilute aqueous sodium bicarbonate, with dilute hydrochloric acid and with water. The washed mixture is then dried over anhydrous magnesium sulfate, filtered and stripped of benzene under reduced pressure to yield the desired product N-(3-nitrophenyl)-β-chloropropionamide as the residue.

後処理

  1. customequipped with a mechanical stirrer
  2. temperaturethermometer and reflux condenser
  3. temperatureThe reaction mixture is heated
  4. temperatureat reflux
  5. washis washed with dilute aqueous sodium bicarbonate, with dilute hydrochloric acid and with water
  6. dry with materialThe washed mixture is then dried over anhydrous magnesium sulfate
  7. filtrationfiltered

出典と根拠

ORDレコード
ord-cebbaf73f2b042388e05a7eb70012b52
出典データセット
uspto-grants-1976_05
特許番号
US03958974

反応ノート

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