Acetone → 2,2,6,6-Tetramethyl-4-piperidone

HRID 1076991

反応式

HRID 1076991 の反応式
[NH3:1].[Cl-].[NH4+].[CH3:4][C:5](=[O:11])[CH2:6][C:7]([CH3:10])(O)[CH3:8].[CH3:12][C:13]([CH3:15])=O>CO>[CH3:8][C:7]1([CH3:10])[CH2:6][C:5](=[O:11])[CH2:4][C:13]([CH3:15])([CH3:12])[NH:1]1

参加物

6

反応物 4

HCID 180Acetone2 回HCID 222AmmoniaHCID 25517Ammonium ChlorideHCID 31256Diacetone Alcohol

生成物 1

HCID 132202,2,6,6-Tetramethyl-4-piperidone収率 42.5%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

40 g of ammonia gas is introduced in the course of about 4 hours at 13°-15°C into a mixture consisting of 126 g of acetone, 22.5 g of methanol and 4.7 g of ammonium chloride. The reaction mixture is subsequently stirred for a further 30 minutes at the same temperature. An addition is then made to the reaction mixture of 220 g of diacetone alcohol and 110 g of acetone; the whole is heated within 1 hour to 55°C and held at this temperature for 12 hours. Processing by fractional distillation yields 125 g of 2,2,6,6-tetramethyl-4-oxopiperidine.

後処理

  1. additionAn addition
  2. temperaturethe whole is heated within 1 hour to 55°C
  3. waitheld at this temperature for 12 hours
  4. distillationProcessing by fractional distillation

出典と根拠

ORDレコード
ord-cf1a88b58c114088b8cc7444358aa2c9
出典データセット
uspto-grants-1976_05
特許番号
US03959295

関連ノート

読み込み中…