tert-Butyl ethyl ethanedioate → HCID 21535782、化合物

HRID 1077055ノート

反応式

HRID 1077055 の反応式
[Li][C:2]#[C:3][CH:4]([CH3:6])[CH3:5].[C:7](OCC)(=[O:15])[C:8]([O:10][C:11]([CH3:14])([CH3:13])[CH3:12])=[O:9]>C1COCC1>[CH3:5][CH:4]([CH3:6])[C:3]#[C:2][C:7](=[O:15])[C:8]([O:10][C:11]([CH3:14])([CH3:13])[CH3:12])=[O:9]

参加物

4

反応物 2

HCID 14648212tert-Butyl ethyl ethanedioateHCID 178506794HCID 178506794、化合物2 回

生成物 1

HCID 21535782HCID 21535782、化合物

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

reacting 1-lithio-3-methylbut-1-yne with a 150% to 165% excess of the stoichiometric amount of ethyl t-butyl oxalate in THF containing an amount of a suitable hydrocarbon solvent sufficient to solubilize said 1-lithio-3-methylbut-1-yne, the reaction being carried out under anhydrous conditions in an inert atmosphere at a temperature of from 0° to 10° C. to form t-butyl 5-methyl-2-oxohex-3-ynoate;

後処理

  1. custombeing carried out under anhydrous conditions in an inert atmosphere at a temperature of from 0° to 10° C.

出典と根拠

ORDレコード
ord-6c0cb0ceaeb3413890dd1589203a63c3
出典データセット
uspto-grants-1976_05
特許番号
US03959312

反応ノート

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