Sodium borohydride → HCID 68143930、化合物

HRID 1077163ノート

反応式

HRID 1077163 の反応式
[CH2:1]([C@:4]12[CH2:12][CH2:11][C:10]3[C:13]4[CH:14]=[CH:15][C:16]([O:21][CH3:22])=[CH:17][C:18]=4[CH2:19][CH2:20][C:9]=3[C@@H:8]1[CH2:7][CH2:6][C:5]2=[O:23])[CH2:2][CH3:3].[BH4-].[Na+]>CO>[CH2:1]([C@:4]12[CH2:12][CH2:11][C:10]3[C:13]4[CH:14]=[CH:15][C:16]([O:21][CH3:22])=[CH:17][C:18]=4[CH2:19][CH2:20][C:9]=3[C@@H:8]1[CH2:7][CH2:6][C@@H:5]2[OH:23])[CH2:2][CH3:3]

参加物

4

反応物 2

HCID 4311764Sodium borohydrideHCID 54182015(±)-3-Methoxy-13-propylgona-1,3,5(10),8-tetraen-17-one

生成物 1

HCID 68143930HCID 68143930、化合物

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

Add 13β-propyl-3-methoxygona-1,3,5(10),8-tetraen-17-one (3.5 g.) to a solution of sodium borohydride (1.16 g.) in methanol (120 cc.). Heat the reaction mixture to reflux with stirring for 30 minutes. Concentrate the resulting solution, adjust its pH to 6 with aqueous acetic acid and filter off the resulting white precipitate which is the title product, (3.1 g.), m.p. 134°-8°; ultra-violet absorption peak at 278 mμ (ε15,350); infrared showed a band due to hydroxyl but no ketone present.

後処理

  1. temperatureHeat the reaction mixture
  2. temperatureto reflux
  3. concentrationConcentrate the resulting solution
  4. filtrationfilter off the resulting white precipitate which

出典と根拠

ORDレコード
ord-3c5969ae87314b1c84ef31762a4adb85
出典データセット
uspto-grants-1976_05
特許番号
US03959322

反応ノート

読み込み中…