Thionyl Chloride → 6,6-Difluorohex-5-enoic acid chloride
反応式
S(Cl)([Cl:3])=O.[F:5][C:6]([F:14])=[CH:7][CH2:8][CH2:9][CH2:10][C:11](O)=[O:12]>CN(C)C=O>[F:5][C:6]([F:14])=[CH:7][CH2:8][CH2:9][CH2:10][C:11]([Cl:3])=[O:12]参加物
4
実験手順
6.5 ml of thionyl chloride are added dropwise, at room temperature, with stirring, to 7.5 g of 6,6-difluorohex-5-enoic acid and a drop of dimethylformamide. The mixture is then stirred at reflux temperature for 5 hours, the excess thionyl chloride is evaporated off in a rotary evaporator and the residue is distilled at 86° and 100 mbar. The title product is obtained in the form of a colourless fluid.
後処理
- temperatureat reflux temperature for 5 hours
- customthe excess thionyl chloride is evaporated off in a rotary evaporator
- distillationthe residue is distilled at 86°
出典と根拠
- ORDレコード
- ord-72862ce59e4449f39f40c28c05ac4502
- 出典データセット
- uspto-grants-1996_08
- 特許番号
- US05545630
反応ノート
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