Sodium Hydroxide → 4'-Methyl-biphenyl-3-carboxylic acid
反応式
[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:13]=[CH:12][CH:11]=[C:10]([C:14]([O:16]CC)=[O:15])[CH:9]=2)=[CH:4][CH:3]=1.[OH-].[Na+]>C(O)C>[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:13]=[CH:12][CH:11]=[C:10]([C:14]([OH:16])=[O:15])[CH:9]=2)=[CH:4][CH:3]=1参加物
4
実験手順
To a solution of ethyl 4'-methylbiphenyl-3-carboxylate (4.0 g) in ethanol (50 ml) was added a solution of 10 ml of 10% aqueous sodium hydroxide, and the mixture refluxed for 2 hours. Solvent was removed under reduced pressure, water added to the residue, and the solution filtered. The filtrate was acidified with dilute hydrochloric acid, and the white solid filtered off and dried under vacuum, yielding 2.4 g of 4'-methylbiphenyl-3-carboxylic acid m.p. 192° C.
後処理
- temperaturethe mixture refluxed for 2 hours
- customSolvent was removed under reduced pressure, water
- additionadded to the residue
- filtrationthe solution filtered
- filtrationthe white solid filtered off
- customdried under vacuum
出典と根拠
- ORDレコード
- ord-caafe567a20a4754856bf9f188721866
- 出典データセット
- uspto-grants-1996_08
- 特許番号
- US05545645
反応ノート
読み込み中…