Sodium Hydroxide → 4'-Methyl-biphenyl-3-carboxylic acid

HRID 1077829

反応式

HRID 1077829 の反応式
[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:13]=[CH:12][CH:11]=[C:10]([C:14]([O:16]CC)=[O:15])[CH:9]=2)=[CH:4][CH:3]=1.[OH-].[Na+]>C(O)C>[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:13]=[CH:12][CH:11]=[C:10]([C:14]([OH:16])=[O:15])[CH:9]=2)=[CH:4][CH:3]=1

参加物

4

反応物 2

HCID 14798Sodium HydroxideHCID 107287544'-Methyl-biphenyl-3-carboxylic acid ethyl ester

生成物 1

HCID 27739784'-Methyl-biphenyl-3-carboxylic acid収率 67.9%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

To a solution of ethyl 4'-methylbiphenyl-3-carboxylate (4.0 g) in ethanol (50 ml) was added a solution of 10 ml of 10% aqueous sodium hydroxide, and the mixture refluxed for 2 hours. Solvent was removed under reduced pressure, water added to the residue, and the solution filtered. The filtrate was acidified with dilute hydrochloric acid, and the white solid filtered off and dried under vacuum, yielding 2.4 g of 4'-methylbiphenyl-3-carboxylic acid m.p. 192° C.

後処理

  1. temperaturethe mixture refluxed for 2 hours
  2. customSolvent was removed under reduced pressure, water
  3. additionadded to the residue
  4. filtrationthe solution filtered
  5. filtrationthe white solid filtered off
  6. customdried under vacuum

出典と根拠

ORDレコード
ord-caafe567a20a4754856bf9f188721866
出典データセット
uspto-grants-1996_08
特許番号
US05545645

関連ノート

読み込み中…