1-Benzyl-4-(1-indolyl)-piperidine → 1-(Piperidin-4-yl)-1H-indole

HRID 1077933ノート

反応式

HRID 1077933 の反応式
C([N:8]1[CH2:13][CH2:12][CH:11]([N:14]2[C:22]3[C:17](=[CH:18][CH:19]=[CH:20][CH:21]=3)[CH:16]=[CH:15]2)[CH2:10][CH2:9]1)C1C=CC=CC=1>[OH-].[OH-].[Pd+2].C(O)(=O)C>[N:14]1([CH:11]2[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]2)[C:22]2[C:17](=[CH:18][CH:19]=[CH:20][CH:21]=2)[CH:16]=[CH:15]1

参加物

4

反応物 1

HCID 212222251-Benzyl-4-(1-indolyl)-piperidine

生成物 1

HCID 140907551-(Piperidin-4-yl)-1H-indole収率 80%

試薬・触媒・溶媒 2

HCID 9942167Palladium hydroxide触媒HCID 176Acetic Acid溶媒

反応条件

温度
80 °C

実験手順

A glacial acetic acid (15 mL) solution containing Pd(OH)2 /C and 1-benzyl-4-(1-indolyl)-piperidine was placed under an H2 atmosphere. The reaction temperature was raised to 80° C. After 1 hour, the reaction was cooled to room temperature and filtered. The filtrate was made basic (pH 8-9) with saturated NaHCO3, and extracted with methylene chloride. The extract was washed with water, dried, and concentrated. This material was sufficiently pure for further reactions giving 1.09 g (80% yield) of the title compound.

後処理

  1. temperaturethe reaction was cooled to room temperature
  2. filtrationfiltered
  3. extractionextracted with methylene chloride
  4. washThe extract was washed with water
  5. customdried
  6. concentrationconcentrated

出典と根拠

ORDレコード
ord-3ca1a08877b24b339fa209fc065331b5
出典データセット
uspto-grants-1996_08
特許番号
US05545636

反応ノート

読み込み中…