Ethyl chloroformate → 4-Indol-1-yl-piperidine-1-carboxylic acid ethyl ester

HRID 1077936ノート

反応式

HRID 1077936 の反応式
C([N:8]1[CH2:13][CH2:12][CH:11]([N:14]2[C:22]3[C:17](=[CH:18][CH:19]=[CH:20][CH:21]=3)[CH:16]=[CH:15]2)[CH2:10][CH2:9]1)C1C=CC=CC=1.Cl[C:24]([O:26][CH2:27][CH3:28])=[O:25]>C(Cl)Cl>[CH2:27]([O:26][C:24]([N:8]1[CH2:13][CH2:12][CH:11]([N:14]2[C:22]3[C:17](=[CH:18][CH:19]=[CH:20][CH:21]=3)[CH:16]=[CH:15]2)[CH2:10][CH2:9]1)=[O:25])[CH3:28]

参加物

4

反応物 2

HCID 10928Ethyl chloroformateHCID 212222251-Benzyl-4-(1-indolyl)-piperidine

生成物 1

HCID 140907494-Indol-1-yl-piperidine-1-carboxylic acid ethyl ester収率 53%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

To a solution of 1-N-(1-benzyl-piperidin-4-yl)-indole (100 g, 0.344 mol) in methylene chloride (1 L) was added ethyl chloroformate (99.2 mL) dropwise with stirring. The mixture was refluxed for 48 hours, cooled to room temperature, and concentrated. The residue was crystallized from i-propanol to give the title compound as colorless crystals (50 g, 53% yield). M. Pt.: 127° C.

後処理

  1. temperatureThe mixture was refluxed for 48 hours
  2. concentrationconcentrated
  3. customThe residue was crystallized from i-propanol

出典と根拠

ORDレコード
ord-7a4a9340f50c410ab2efb3ae3338d6e7
出典データセット
uspto-grants-1996_08
特許番号
US05545636

反応ノート

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