Pyridine → HCID 54390883、化合物

HRID 1078031ノート

反応式

HRID 1078031 の反応式
[F:1][C@H:2]([CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH3:10])[CH2:3][OH:4].N1C=CC=CC=1.[S:17](Cl)([C:20]1[CH:26]=[CH:25][C:23]([CH3:24])=[CH:22][CH:21]=1)(=[O:19])=[O:18]>O>[S:17]([C:20]1[CH:26]=[CH:25][C:23]([CH3:24])=[CH:22][CH:21]=1)([O:4][CH2:3][C@H:2]([F:1])[CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH3:10])(=[O:19])=[O:18]

参加物

5

反応物 3

HCID 1049PyridineHCID 73974-Toluenesulfonyl chlorideHCID 10855629(R)-(+)-2-fluorooctanol

生成物 1

HCID 54390883HCID 54390883、化合物収率 93.1%

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

A reaction vessel was charged with 10.0 g of (2R)-2fluorooctanol and 25 ml of pyridine, and 13.0 g of tosyl chloride was added with stirring at 0°-5° C. After the reaction was effected for 6 hours, the mixture was poured into water and extracted with 100 ml of benzene. The resultant solution in benzene was washed sequentially with water, an aqueous solution of NaHCO3 and water in that order, and dried over Glauber's salt. The solvent was distilled off to obtain 19.0 g (yield 92.6%) of crude (2R)-2-fluorooctyl tosylate as the residue.

後処理

  1. additionwas added
  2. extractionextracted with 100 ml of benzene
  3. washThe resultant solution in benzene was washed sequentially with water
  4. dry with materialan aqueous solution of NaHCO3 and water in that order, and dried over Glauber's salt
  5. distillationThe solvent was distilled off

出典と根拠

ORDレコード
ord-7092816a216d428eb96c78ed3903ba42
出典データセット
uspto-grants-1996_08
特許番号
US05545747

反応ノート

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