Ethyl 4-bromo-2-butenoate → HCID 54263662、化合物
反応式
[Na].[OH:2][C:3]1[CH:8]=[CH:7][C:6]([N+:9]([O-:11])=[O:10])=[CH:5][C:4]=1[NH:12]C(=O)C(F)(F)F.Br[CH2:20][CH:21]=[CH:22][C:23]([O:25][CH2:26][CH3:27])=[O:24]>C(O)C>[N+:9]([C:6]1[CH:7]=[CH:8][C:3]2[O:2][CH2:20][CH:21]([CH2:22][C:23]([O:25][CH2:26][CH3:27])=[O:24])[NH:12][C:4]=2[CH:5]=1)([O-:11])=[O:10]参加物
5
反応条件
- 温度
- 0 °C
実験手順
220 ml of ethanol are introduced into a 1 l three-necked flask, with magnetic stirring, cooled to 0° C., and 3 g (0.133 mol) of sodium are added slowly, in small portions, followed by successive dropwise addition of 22.29 g (0.088 mol) of N-(2-hydroxy-5-nitrophenyl)trifluoroacetamide and 22.65 g (0.088 mol) of 75% pure ethyl 4-bromo-2-butenoate, and the mixture is heated at reflux for 3 h.