Chlorpromazine Hydrochloride → Chlorpromazine

HRID 1078635ノート

反応式

HRID 1078635 の反応式
Cl.[Cl:2][C:3]1[CH:16]=[CH:15][C:14]2[S:13][C:12]3[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=3)[N:6]([CH2:17][CH2:18][CH2:19][N:20]([CH3:22])[CH3:21])[C:5]=2[CH:4]=1.[OH-].[Na+]>>[Cl:2][C:3]1[CH:16]=[CH:15][C:14]2[S:13][C:12]3[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=3)[N:6]([CH2:17][CH2:18][CH2:19][N:20]([CH3:21])[CH3:22])[C:5]=2[CH:4]=1

参加物

3

反応物 2

HCID 6240Chlorpromazine HydrochlorideHCID 14798Sodium Hydroxide

生成物 1

HCID 2726Chlorpromazine収率 98.2%

実験手順

3.56 g (10 mmol) of 2-chloro-10-(3-dimethylaminopropyl) phenothiazine hydrochloride are suspended in 15 ml of a 1N sodium hydroxide solution. The amine freed is extracted with diethyl ether. The organic phase is decanted and dried over sodium sulfate and then evaporated to dryness to yield 3.13 g of an oil corresponding to the expected product.

後処理

  1. extractionThe amine freed is extracted with diethyl ether
  2. customThe organic phase is decanted
  3. dry with materialdried over sodium sulfate
  4. customevaporated to dryness

出典と根拠

ORDレコード
ord-6f47e1eebbe94bdf9ef4f03fdbb629a8
出典データセット
uspto-grants-1996_08
特許番号
US05550143

反応ノート

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