Hydrochloric Acid → 1-(3-Aminophenyl)piperidine dihydrochloride

HRID 1079398ノート

反応式

HRID 1079398 の反応式
[N+:1]([C:4]1[CH:5]=[C:6]([N:10]2[CH2:15][CH2:14][CH2:13][CH2:12][CH2:11]2)[CH:7]=[CH:8][CH:9]=1)([O-])=O.[ClH:16]>CO.[Pd]>[ClH:16].[ClH:16].[NH2:1][C:4]1[CH:5]=[C:6]([N:10]2[CH2:15][CH2:14][CH2:13][CH2:12][CH2:11]2)[CH:7]=[CH:8][CH:9]=1

参加物

5

反応物 2

HCID 313Hydrochloric AcidHCID 147652751-(3-Nitrophenyl)piperidine

生成物 1

HCID 233669441-(3-Aminophenyl)piperidine dihydrochloride

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 887Methanol溶媒

実験手順

To a solution of N-(3-nitrophenyl)piperidine (12 g) in methanol (50 ml) was added conc. hydrochloric acid (12 ml) and, by using 10% palladium/carbon as a catalyst, catalytic reduction was conducted at normal temperature under normal pressure. After completion of the reaction, the catalyst was removed and the solvent was distilled off. Ethyl ether was added to the residue and the mixture was filtered off to obtain N-(3-aminophenyl)piperidine dihydrochloride (13.2 g) as a colorless solid.

後処理

  1. customAfter completion of the reaction
  2. customthe catalyst was removed
  3. distillationthe solvent was distilled off
  4. additionEthyl ether was added to the residue
  5. filtrationthe mixture was filtered off

出典と根拠

ORDレコード
ord-d3a17d2545f9416e8816ac7874cbd5ba
出典データセット
uspto-grants-1996_12
特許番号
US05580883

反応ノート

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