Acetonitrile → 1-(2-Fluoro-5-pyridylmethyl) 2-(nitroimino)imidazolidine

HRID 1079423ノート

反応式

HRID 1079423 の反応式
[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8]Br)=[CH:4][N:3]=1.[N+:10]([N:13]=[C:14]1[NH:18][CH2:17][CH2:16][NH:15]1)([O-:12])=[O:11].C(=O)([O-])[O-].[K+].[K+].C(#N)C>O>[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][N:15]2[CH2:16][CH2:17][NH:18][C:14]2=[N:13][N+:10]([O-:12])=[O:11])=[CH:4][N:3]=1

参加物

6

反応物 4

HCID 6342AcetonitrileHCID 11430Potassium CarbonateHCID 220506385-(Bromomethyl)-2-fluoropyridineHCID 135413413N-nitroimidazolidin-2-imine

生成物 1

HCID 1363427881-(2-Fluoro-5-pyridylmethyl) 2-(nitroimino)imidazolidine収率 50.2%

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

A mixture of 2-fluoro-5-pyridylmethyl bromide (9.5 g), 2-(nitroimino)imidazolidine (6.5 g), potassium carbonate (7.6 g) and acetonitrile (100 ml) was refluxed for 2 hours with stirring. After the reaction, the reaction mixture was cooled to room temperature, and cold water (100 ml) was added. The resulting crystals were collected by filtration and washed with ether to give slightly colored 1-(2-fluoro-5-pyridylmethyl)-2-(nitroimino)imidazolidine (6.0 g) as the desired compound.

後処理

  1. temperaturewas refluxed for 2 hours
  2. customAfter the reaction
  3. filtrationThe resulting crystals were collected by filtration
  4. washwashed with ether

出典と根拠

ORDレコード
ord-5ea5267432cb4b559d1e791910d125b4
出典データセット
uspto-grants-1996_12
特許番号
US05580889

反応ノート

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