Sodium borohydride → Methyl thien-2-yl-hydroxyacetate

HRID 1080710ノート

反応式

HRID 1080710 の反応式
[S:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[C:6](=[O:11])[C:7]([O:9][CH3:10])=[O:8].[BH4-].[Na+]>C(O)C.O>[OH:11][CH:6]([C:2]1[S:1][CH:5]=[CH:4][CH:3]=1)[C:7]([O:9][CH3:10])=[O:8]

参加物

5

反応物 2

HCID 4311764Sodium borohydrideHCID 11217486Methyl alpha-oxo-2-thiopheneacetate

生成物 1

HCID 13682356Methyl thien-2-yl-hydroxyacetate収率 88.4%

試薬・触媒・溶媒 2

HCID 702Ethanol溶媒HCID 962Water溶媒

実験手順

To a stirred solution of methyl 2-thiopheneglyoxylate (1.01 g) in ethanol (20 ml) in an ice bath was added sodium borohydride (0.113 g) in 1 ml of water, and the mixture was stirred for 10 minutes. The reaction was quenched with aqueous acetic acid and the mixture was partitioned between methylene chloride and water. The organic extract was washed with brine, dried (sodium sulfate) and evaporated to give methyl α-hydroxy-2-thienylacetate as an oil (0.903 g).

後処理

  1. customThe reaction was quenched with aqueous acetic acid
  2. customthe mixture was partitioned between methylene chloride and water
  3. extractionThe organic extract
  4. washwas washed with brine
  5. dry with materialdried (sodium sulfate)
  6. customevaporated

出典と根拠

ORDレコード
ord-657ee4f9087f4328a004c25ec7dafb83
出典データセット
uspto-grants-1996_12
特許番号
US05583147

反応ノート

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