Phthalic Anhydride → 2-(2-Thienylcarbonyl)benzoic acid

HRID 1081327ノート

反応式

HRID 1081327 の反応式
[C:1]1(=[O:11])[O:6][C:4](=[O:5])[C:3]2=[CH:7][CH:8]=[CH:9][CH:10]=[C:2]12.[Cl-].[Al+3].[Cl-].[Cl-].[S:16]1[CH:20]=[CH:19][CH:18]=[CH:17]1>ClCCl>[S:16]1[CH:20]=[CH:19][CH:18]=[C:17]1[C:4]([C:3]1[CH:7]=[CH:8][CH:9]=[CH:10][C:2]=1[C:1]([OH:6])=[O:11])=[O:5]

参加物

5

反応物 3

HCID 6811Phthalic AnhydrideHCID 8030ThiopheneHCID 6451240Aluminum(III) Chloride

生成物 1

HCID 2826542-(2-Thienylcarbonyl)benzoic acid収率 61.6%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒2 回

実験手順

To a mixture of phthalic anhydride (2.96 g), dichloromethane (10 ml) and aluminum chloride (5.87 g) was added a solution of thiophene (1.6 g) in dichloromethane, in limited amounts, while stirring at room temperature, then the reaction mixture was stirred for one hour at room temperature. The reaction mixture was poured into HCl-ice water, followed by extraction with ethyl acetate. The extract solution was washed with water and dried, then the solvent was distilled off to leave 2-(2-thienylcarbonyl)benzoic acid as colorless crystals (2.72 g).

後処理

  1. stirringthe reaction mixture was stirred for one hour at room temperature
  2. extractionfollowed by extraction with ethyl acetate
  3. washThe extract solution was washed with water
  4. customdried
  5. distillationthe solvent was distilled off

出典と根拠

ORDレコード
ord-2962e87f8c1945adb12bf8eab97da383
出典データセット
uspto-grants-1996_12
特許番号
US05585385

反応ノート

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