Oxalyl chloride → 2-Methyl-3,4,6-trifluorobenzoyl chloride

HRID 1081402

反応式

HRID 1081402 の反応式
[F:1][C:2]1[CH:10]=[C:9]([F:11])[C:8]([F:12])=[C:7]([CH3:13])[C:3]=1[C:4](O)=[O:5].C(Cl)(=O)C([Cl:17])=O>CN(C=O)C.ClCCl>[F:1][C:2]1[CH:10]=[C:9]([F:11])[C:8]([F:12])=[C:7]([CH3:13])[C:3]=1[C:4]([Cl:17])=[O:5]

参加物

5

反応物 2

HCID 65578Oxalyl chlorideHCID 101303052-Methyl-3,4,6-trifluorobenzoic acid

生成物 1

HCID 150076072-Methyl-3,4,6-trifluorobenzoyl chloride収率 99%

試薬・触媒・溶媒 2

HCID 6228Dimethylformamide触媒HCID 6344Dichloromethane溶媒

実験手順

A solution of 5.8 g (30.5 mmol) of 2,4,5-trifluoro- 6-methylbenzoic acid, 4.7 g (37.0 mmol) of oxalyl chloride, and 100 mL of dichloromethane was treated with three drops of DMF. The reaction mixture was stirred at room temperature for 2 hours, then concentrated to give 6.3 g of the title compound as an oily solid. The product was used "as is" in the next step.

後処理

  1. concentrationconcentrated

出典と根拠

ORDレコード
ord-03d9906dc62b4e37b49606ae98496391
出典データセット
uspto-grants-1996_12
特許番号
US05585491

関連ノート

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