HCID 86750087、化合物 → (+)-cis-4-Amino-1-benzyl-3-methyl-2-oxopyrrolidine
反応式
[CH2:1]([N:8]1[CH2:12][C@H:11]([NH:13]C(OC(C)(C)C)=O)[C@H:10]([CH3:21])[C:9]1=[O:22])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1>FC(F)(F)C(O)=O>[NH2:13][C@H:11]1[CH2:12][N:8]([CH2:1][C:2]2[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=2)[C:9](=[O:22])[C@H:10]1[CH3:21]参加物
3
実験手順
In 15 ml of trifluoroacetic acid was dissolved 1.76 g of Compound (44). After 1 hour, the solution was concentrated under reduced pressure. To the residue was added 100 ml of water, and the mixture was washed with benzene. The aqueous layer was adjusted to a pH of 12 with sodium hydroxide and extracted with chloroform. The organic layer was dried over anhydrous sodium sulfate, and the solvent was evaporated to obtain the titled compound (45) as a colorless oil.
後処理
- concentrationthe solution was concentrated under reduced pressure
- additionTo the residue was added 100 ml of water
- washthe mixture was washed with benzene
- extractionextracted with chloroform
- dry with materialThe organic layer was dried over anhydrous sodium sulfate
- customthe solvent was evaporated
出典と根拠
- ORDレコード
- ord-075ab613c908415697ab87f9396b4b0a
- 出典データセット
- uspto-grants-1996_12
- 特許番号
- US05587386
反応ノート
読み込み中…