Acetonitrile → 5-[3-(Benzenesulfonamido)propyloxy]imidazo[1,2-a]pyridine

HRID 1081731

反応式

HRID 1081731 の反応式
Cl.Cl.[NH2:3][CH2:4][CH2:5][CH2:6][O:7][C:8]1[N:13]2[CH:14]=[CH:15][N:16]=[C:12]2[CH:11]=[CH:10][CH:9]=1.C(N(CC)CC)C.C(#N)C.[C:27]1([S:33](Cl)(=[O:35])=[O:34])[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=1>C(Cl)Cl>[C:27]1([S:33]([NH:3][CH2:4][CH2:5][CH2:6][O:7][C:8]2[N:13]3[CH:14]=[CH:15][N:16]=[C:12]3[CH:11]=[CH:10][CH:9]=2)(=[O:35])=[O:34])[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=1

参加物

6

反応物 4

HCID 6342AcetonitrileHCID 7369Benzenesulfonyl chlorideHCID 8471TriethylamineHCID 233629975-[3-(Amino)propyloxy]imidazo[1,2-a]pyridine dihydrochloride

生成物 1

HCID 233629785-[3-(Benzenesulfonamido)propyloxy]imidazo[1,2-a]pyridine収率 59.5%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

To a suspension of 5-[3-(amino)propyloxy]imidazo[1,2-a]pyridine dihydrochloride (2.64 g, 10 mmoles) and triethylamine (4.88 ml, 35 mmoles) in methylene chloride (100 ml)-acetonitrile (30 ml) was added benzenesulfonyl chloride (1.53 ml, 12 mmoles) under ice-cooling with stirring and the mixture was stirred at room temperature for hour. The reaction mixture was washed in turn with an aqueous sodium bicarbonate solution and saturated saline and dried over anhydrous magnesium sulfate. After the solvent was distilled off, the crude product thus obtained was recrystallized from methylene-ethanol to obtain 1.97 g of the desired product (59.5%, light brown crystals).

後処理

  1. temperaturecooling
  2. stirringthe mixture was stirred at room temperature for hour
  3. washThe reaction mixture was washed in turn with an aqueous sodium bicarbonate solution and saturated saline
  4. dry with materialdried over anhydrous magnesium sulfate
  5. distillationAfter the solvent was distilled off
  6. customthe crude product thus obtained
  7. customwas recrystallized from methylene-ethanol

出典と根拠

ORDレコード
ord-c56ed5989ed84cc5bfbbb44632686694
出典データセット
uspto-grants-1996_12
特許番号
US05587383

関連ノート

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