Tetrahydrofuran → 3-Amino-5-chloro-4-methyl-6-(3-pyridin-2-yl-propoxy)-thieno[2,3-b]pyridine-2-carboxylic acid cyclopropylamide

HRID 108280

反応式

[CH2:42]1[O:43][CH2:44][CH2:45][CH2:46]1.[CH3:11][Si:12]([N-:13][Si:14]([CH3:15])([CH3:16])[CH3:17])([CH3:18])[CH3:19].[CH:21]1([NH:24][C:25](=[O:26])[c:27]2[c:28]([NH2:41])[c:29]3[c:30]([n:31][c:32]([S:37]([CH3:38])=[O:39])[c:33]([Cl:36])[c:34]3[CH3:35])[s:40]2)[CH2:22][CH2:23]1.[Li+:20].[n:1]1[c:2]([CH2:7][CH2:8][CH2:9][OH:10])[cH:3][cH:4][cH:5][cH:6]1>>[n:1]1[c:2]([CH2:7][CH2:8][CH2:9][O:10][c:32]2[n:31][c:30]3[c:29]([c:28]([NH2:41])[c:27]([C:25]([NH:24][CH:21]4[CH2:22][CH2:23]4)=[O:26])[s:40]3)[c:34]([CH3:35])[c:33]2[Cl:36])[cH:3][cH:4][cH:5][cH:6]1