Isophthalaldehyde → 3-(2-(6-Phenylpyridin-2-yl)ethenyl)benzaldehyde

HRID 1084425

反応式

HRID 1084425 の反応式
[CH3:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)[N:3]=1.[CH:14](=O)[C:15]1[CH:22]=[CH:21][CH:20]=[C:17]([CH:18]=[O:19])[CH:16]=1>[Cl-].[Zn+2].[Cl-]>[C:8]1([C:4]2[N:3]=[C:2]([CH:1]=[CH:14][C:15]3[CH:16]=[C:17]([CH:20]=[CH:21][CH:22]=3)[CH:18]=[O:19])[CH:7]=[CH:6][CH:5]=2)[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1

参加物

4

反応物 2

HCID 34777IsophthalaldehydeHCID 27628852-Methyl-6-phenylpyridine

生成物 1

HCID 539539623-(2-(6-Phenylpyridin-2-yl)ethenyl)benzaldehyde

試薬・触媒・溶媒 1

HCID 3007855Zincchloride触媒

反応条件

温度
160 °C

実験手順

A mixture of 2-methyl-6-phenylpyridine (525 mg) (step 2), isophthalaldehyde (630 mg) and dry zinc chloride (40 mg) was heated at 160° C. under N2 for 3 hours. The resulting mixture was partitioned between 25% aqueous NH40Ac (20 cc) and ethyl acetate (20 cc) The organic layer was washed with H2O (10 cc), brine and solvent as removed in vacuo. The residue was purified by chromatography to afford the title compound.

後処理

  1. customThe resulting mixture was partitioned between 25% aqueous NH40Ac (20 cc) and ethyl acetate (20 cc) The organic layer
  2. washwas washed with H2O (10 cc), brine and solvent
  3. customas removed in vacuo
  4. customThe residue was purified by chromatography

出典と根拠

ORDレコード
ord-f283381da93346dab8a20399803753e3
出典データセット
uspto-grants-1991_04
特許番号
US05004743

関連ノート

読み込み中…