Thionyl Chloride → HCID 20063341、化合物

反応式

[F:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[C:17]([C:18](O)=[O:19])=[C:16]([CH:21]([CH3:23])[CH3:22])[C:15]3[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=3)[C:9]2=[O:24])=[CH:4][CH:3]=1.S(Cl)([Cl:27])=O>>[F:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[C:17]([C:18]([Cl:27])=[O:19])=[C:16]([CH:21]([CH3:23])[CH3:22])[C:15]3[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=3)[C:9]2=[O:24])=[CH:4][CH:3]=1

参加物

反応物 2

HCID 24386Thionyl Chloride

HCID 20063357HCID 20063357、化合物

生成物 1

HCID 20063341HCID 20063341、化合物

実験手順

A mixture of 2-(4-fluorophenyl)-4-isopropyl-1-oxo-1,2-dihydroisoquinoline-3-carboxylic acid (19.9 g) and thionyl chloride (213 ml) was refluxed for 90 minutes. Excess thionyl chloride was removed in vacuo to give crude 2-(4-fluorophenyl)-4-isopropyl-1-oxo-1,2-dihydroisoquinoline-3-carbonyl chloride (21 g) in the form of a grey/green solid, m.p. 113°-115° C. [Elemental analysis: C, 66.2; H, 4.49; N, 4.06; Cl, 10.8%; calculated: C, 66.4; H, 4.40; N, 4.07; Cl, 10.3%].

後処理

temperaturewas refluxed for 90 minutes
customExcess thionyl chloride was removed in vacuo

出典と根拠

ORDレコード: ord-2f38581c22a743b2b1b93bd2fb0ebfd5
出典データセット: uspto-grants-1991_04
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US05004747

反応ノート

読み込み中…