Dicyclohexylcarbodiimide → HCID 14208221、化合物

HRID 1084580ノート

反応式

HRID 1084580 の反応式
[C:1]([NH:8][C@@H:9]([C:17]([OH:19])=O)[CH2:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1)([O:3][C:4]([CH3:7])([CH3:6])[CH3:5])=[O:2].[NH2:20][C@H:21]1[N:27]=[C:26]([C:28]2[CH:33]=[CH:32][CH:31]=[CH:30][C:29]=2[F:34])[C:25]2[CH:35]=[CH:36][CH:37]=[CH:38][C:24]=2[N:23]([CH3:39])[C:22]1=[O:40].C1(N=C=NC2CCCCC2)CCCCC1>>[CH3:7][C:4]([O:3][C:1](=[O:2])[NH:8][CH:9]([CH2:10][C:11]1[CH:12]=[CH:13][CH:14]=[CH:15][CH:16]=1)[C:17]([NH:20][CH:21]1[N:27]=[C:26]([C:28]2[CH:33]=[CH:32][CH:31]=[CH:30][C:29]=2[F:34])[C:25]2[CH:35]=[CH:36][CH:37]=[CH:38][C:24]=2[N:23]([CH3:39])[C:22]1=[O:40])=[O:19])([CH3:5])[CH3:6]

参加物

4

反応物 3

HCID 10868DicyclohexylcarbodiimideHCID 637610Boc-D-phenylalanineHCID 14423346HCID 14423346、化合物

生成物 1

HCID 14208221HCID 14208221、化合物

実験手順

The procedure of Example 77 was carried out in which Boc-D-phenylalanine was coupled to 3(S)-(-)-amino-1,3-dihydro-1-methyl-5-(2-fluorophenyl)-2H-1,4-benzodiazepin-2-one with dicyclohexylcarbodiimide. Following the identical work-up and purification procedure of Example 77 gave the analytical product.

後処理

  1. customthe identical work-up and purification procedure of Example 77
  2. customgave the analytical product

出典と根拠

ORDレコード
ord-bfdb1560e7584e41bf33d07972351a72
出典データセット
uspto-grants-1991_04
特許番号
US05004741

反応ノート

読み込み中…