Propargyl bromide → 4,9-Dihydro-3-methyl-4-(prop-2-ynyl)-10H-thieno[3,4-b][1,5]benzodiazepin-10-one

HRID 1084715ノート

反応式

HRID 1084715 の反応式
[CH3:1][C:2]1[S:3][CH:4]=[C:5]2[C:11](=[O:12])[NH:10][C:9]3[CH:13]=[CH:14][CH:15]=[CH:16][C:8]=3[NH:7][C:6]=12.Br[CH2:18][C:19]#[CH:20].C([Li])CCC>O1CCCC1>[CH3:1][C:2]1[S:3][CH:4]=[C:5]2[C:11](=[O:12])[NH:10][C:9]3[CH:13]=[CH:14][CH:15]=[CH:16][C:8]=3[N:7]([CH2:20][C:19]#[CH:18])[C:6]=12

参加物

5

反応物 3

HCID 7842Propargyl bromideHCID 126587009,10-dihydro-3-methyl-4H-thieno[3,4-b][1,5]benzodiazepin-10-oneHCID 178418339Butyllithium

生成物 1

HCID 200624924,9-Dihydro-3-methyl-4-(prop-2-ynyl)-10H-thieno[3,4-b][1,5]benzodiazepin-10-one収率 50%

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

Prepared analogously to Example la) from 4,9-dihydro-3-methyl-10H-thieno[3,4-b][1,5]benzodiazepin-10-one and 3-bromo-prop-1-yne in the presence of butyllithium and tetrahydrofuran in a yield of 50% of theory. The crude crystalline product was used for subsequent reactions without being further purified by chromatography.

後処理

  1. customwithout being further purified by chromatography

出典と根拠

ORDレコード
ord-57fe840065ca4fbe9ee5422a49d492c2
出典データセット
uspto-grants-1991_04
特許番号
US05006522

反応ノート

読み込み中…