Water → 4-(Trifluoromethoxy)benzenemethanol

HRID 1084788

反応式

HRID 1084788 の反応式
[H-].[Al+3].[Li+].[H-].[H-].[H-].[F:7][C:8]([F:19])([F:18])[O:9][C:10]1[CH:17]=[CH:16][C:13]([C:14]#N)=[CH:12][CH:11]=1.[OH2:20].[OH-].[Na+]>C(OCC)C>[F:7][C:8]([F:19])([F:18])[O:9][C:10]1[CH:17]=[CH:16][C:13]([CH2:14][OH:20])=[CH:12][CH:11]=1

参加物

6

反応物 4

HCID 962Water2 回HCID 14798Sodium HydroxideHCID 676214-(Trifluoromethoxy)benzonitrileHCID 21226445Aluminium lithium hydride

生成物 1

HCID 1371844-(Trifluoromethoxy)benzenemethanol

試薬・触媒・溶媒 1

HCID 3283Diethyl Ether溶媒2 回

実験手順

A solution of lithium aluminium hydride in diethyl ether (1.0M, 69.4 ml) was added dropwise to a stirred solution of 4-(trifluoromethoxy)benzonitrile (6.0 g) in diethyl ether (120 ml) over 15 minutes. Water (2.66 ml), 10% sodium hydroxide solution (2.66 ml) and water (7.98 ml) were then added successively, dropwise. The precipitated solid was filtered off and washed with diethyl ether. The filtrate and washings were combined and evaporated under reduced pressure to give 4-(trifluoromethoxy)benzyl alcohol, N.M.R. in deuteriochloroform: δ2.3 (1H,s), 4.65 (2H,s), 7.2 (2H,d), 7.35 (2H,d).

後処理

  1. filtrationThe precipitated solid was filtered off
  2. washwashed with diethyl ether
  3. customevaporated under reduced pressure

出典と根拠

ORDレコード
ord-8a6c4f1d475c48e5b81e3b4d865e66ef
出典データセット
uspto-grants-1991_04
特許番号
US05006543

関連ノート

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