Dimethylformamide → HCID 898498、化合物

HRID 1084825ノート

反応式

HRID 1084825 の反応式
[S:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[CH:6]=[CH:7][C:8]([NH:10][C:11]1[CH:19]=[CH:18][CH:17]=[CH:16][C:12]=1[C:13]([OH:15])=[O:14])=[O:9].C(=O)([O-])[O-].[K+].[K+].CN(C)C=O.[CH2:31](I)[CH3:32]>CC(C)=O>[S:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[CH:6]=[CH:7][C:8]([NH:10][C:11]1[CH:19]=[CH:18][CH:17]=[CH:16][C:12]=1[C:13]([O:15][CH2:31][CH3:32])=[O:14])=[O:9]

参加物

6

反応物 4

HCID 6228Dimethylformamide2 回HCID 6340IodoethaneHCID 11430Potassium CarbonateHCID 3063368HCID 3063368、化合物

生成物 1

HCID 898498HCID 898498、化合物収率 65.4%

試薬・触媒・溶媒 1

HCID 180Acetone溶媒

反応条件

温度
60 °C

実験手順

To a suspension of 2-[3-(2-thienyl)acrylamido]benzoic acid (273 mg, 1 mmol) in acetone (2 ml) were added potassium carbonate (194 mg, 1.4 mmol) and dry dimethylformamide (1 ml). To the resulting solution, ethyl iodide (218 mg, 1.4 mmol) and dry dimethylformamide (2 ml) were added and the mixture was stirred at 60° C. for 1 hour. The reaction mixture was poured into ice water. The precipitated solid was collected by suction, and recrystallized from methanol to give pale yellow crystals of the desired compound (197 mg, yield, 65%). m.p., 120°-122° C.

後処理

  1. customThe precipitated solid was collected by suction
  2. customrecrystallized from methanol

出典と根拠

ORDレコード
ord-51c3f0397e8f469bb8be3e0dffc61165
出典データセット
uspto-grants-1991_04
特許番号
US05006548

反応ノート

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