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8-Hydroxyquinoline → Acetamide, N-(2-methoxyphenyl)-
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 8-Hydroxyquinoline | HCID 1923 | — |
| 反応物 | 2'-Bromoacetanilide | HCID 136416 | — |
| 反応物 | Sodium Methoxide | HCID 10942334 | — |
| 触媒 | Copper | HCID 23978 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 生成物 | Acetamide, N-(2-methoxyphenyl)- | HCID 7135 | 866.6% |
反応手順
2.3 ml of a 28% solution of sodium methoxide in methanol and 63 mg of copper powder were added to 40 ml of methanol, and the mixture was heated under reflux for 1 hour. Then, 145 mg of 8-hydroxyquinoline and 2.14 g of 2-bromo-1-acetylaminobenzene were added thereto, and the mixture was heated under reflux for 3 hours. The reaction mixture was treated in a usual manner, to obtain 1.43 g (yield: 87%) of the desired compound.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05006660 |
| 出典データセット | uspto-grants-1991_04 |
| ORD ID | ord-e8e0abe2a99d4208807a76251ef34c06 |
| 出典メモ | uspto-grants-1991_04 |