2-Acetoxymethyl-4-cyclopropylmethoxy pyridine → 4-Cyclopropylmethoxy-2-hydroxymethylpyridine

HRID 1085108ノート

反応式

HRID 1085108 の反応式
C([O:4][CH2:5][C:6]1[CH:11]=[C:10]([O:12][CH2:13][CH:14]2[CH2:16][CH2:15]2)[CH:9]=[CH:8][N:7]=1)(=O)C>[OH-].[Na+]>[CH:14]1([CH2:13][O:12][C:10]2[CH:9]=[CH:8][N:7]=[C:6]([CH2:5][OH:4])[CH:11]=2)[CH2:15][CH2:16]1

参加物

3

反応物 1

HCID 156624932-Acetoxymethyl-4-cyclopropylmethoxy pyridine

生成物 1

HCID 108450754-Cyclopropylmethoxy-2-hydroxymethylpyridine

試薬・触媒・溶媒 1

HCID 14798Sodium Hydroxide溶媒

実験手順

To the crude 2-acetoxymethyl-4-cyclopropylmethoxy pyridine, NaOH (100 ml 2M) was added and the mixture was refluxed for 2 hours. The mixture was extracted with methylene chloride, and the phases were separated. The organic layer was dried with Na2SO4, filtered and the solvent was evaporated off, yielding 2.7 g of crude title compound. NMR data is given below. The crude product was used without any further purification.

後処理

  1. temperaturethe mixture was refluxed for 2 hours
  2. extractionThe mixture was extracted with methylene chloride
  3. customthe phases were separated
  4. dry with materialThe organic layer was dried with Na2SO4
  5. filtrationfiltered
  6. customthe solvent was evaporated off

出典と根拠

ORDレコード
ord-0bab58239c9e4a0dbd633075ff94882b
出典データセット
uspto-grants-1991_04
特許番号
US05008278

反応ノート

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