Chlorosuccinimide → 5-Chloro-1-(4-cyanophenyl)-2-methylimidazole
反応式
[C:1]([C:3]1[CH:8]=[CH:7][C:6]([N:9]2[CH:13]=[CH:12][N:11]=[C:10]2[CH3:14])=[CH:5][CH:4]=1)#[N:2].[Cl:15]N1C(=O)CCC1=O>C(Cl)(Cl)Cl>[Cl:15][C:13]1[N:9]([C:6]2[CH:5]=[CH:4][C:3]([C:1]#[N:2])=[CH:8][CH:7]=2)[C:10]([CH3:14])=[N:11][CH:12]=1参加物
4
実験手順
A solution of 1-(4-cyanophenyl)-2-methylimidazole (3 g, 16.4 mmol) and N-chlorosuccinimide (2.18 g, 16.3 mmol) in chloroform (180 ml) was heated at reflux for 4 hours, then washed with water, dried over magnesium sulphate and evaporated to a yellow solid. Trituration with ether left a pale-yellow solid (2.38 g, 67%).
後処理
- temperatureat reflux for 4 hours
- washwashed with water
- dry with materialdried over magnesium sulphate
- customevaporated to a yellow solid
- waitTrituration with ether left a pale-yellow solid (2.38 g, 67%)
出典と根拠
- ORDレコード
- ord-8129d1d277e145ec8eda82bcf372b7db
- 出典データセット
- uspto-grants-1991_04
- 特許番号
- US05008263
反応ノート
読み込み中…