HCID 18769508、化合物 → 4,5-Diamino-3-methyl-1H-pyrazole-1-ethanol

HRID 1085154ノート

反応式

HRID 1085154 の反応式
[NH2:1][C:2]1[N:6]([CH2:7][CH2:8][OH:9])[N:5]=[C:4]([CH3:10])[C:3]=1[N:11]=O>C(O)C.ClCCl.[Pd]>[NH2:11][C:3]1[C:4]([CH3:10])=[N:5][N:6]([CH2:7][CH2:8][OH:9])[C:2]=1[NH2:1]

参加物

5

反応物 1

HCID 18769508HCID 18769508、化合物

生成物 1

HCID 101978014,5-Diamino-3-methyl-1H-pyrazole-1-ethanol収率 97%

試薬・触媒・溶媒 3

HCID 23938Palladium触媒HCID 702Ethanol溶媒HCID 6344Dichloromethane溶媒

実験手順

5-Amino-1-(2-hydroxyethyl)-3-methyl-4-nitrosopyrazole (0.9 g, 5.3 mmole) was dissolved in a mixture of ethanol (40 ml) and dichloromethane (40 ml) and hydrogenated over 10% Pd/C (0.1 g) at 20 p.s.i. and 20° C. for 2 hours. The catalyst was filtered onto Arbocel and the solvent removed under reduced pressure yielding the title compound as a foam (800 mg, 97%).

後処理

  1. filtrationThe catalyst was filtered onto Arbocel
  2. customthe solvent removed under reduced pressure

出典と根拠

ORDレコード
ord-14456989af0249a0a6e2a7357d5116a5
出典データセット
uspto-grants-1991_04
特許番号
US05008263

反応ノート

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