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Triethylamine → 1,3-Dimethyl-6-(piperazin-1-yl)pyrimidine-2,4(1H,3H)-dione
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Triethylamine | HCID 8471 | — |
| 反応物 | N-(2-Bromoethyl)-p-nitrobenzamide | HCID 458985 | — |
| 反応物 | 1,3-Dimethyl-6-(piperazin-1-yl)pyrimidine-2,4(1H,3H)-dione | HCID 12816873 | — |
| 溶媒 | Isopropanol | HCID 3776 | — |
| 生成物 | 1,3-Dimethyl-6-(piperazin-1-yl)pyrimidine-2,4(1H,3H)-dione | HCID 12816873 | — |
| 生成物 | 1,3-dimethyl-6-[4-(4-nitrophenyl)piperazin-1-yl]-2,4(1H,3H)-pyrimidinedione | HCID 20061078 | — |
反応手順
A mixture of 1.3 g of the compound 46 obtained in the paragraph (1), 1.8 g of 1,3-dimethyl-6-(1-piperazinyl)-2,4(1H,3H)pyrimidinedione (compound 37), 1.3 ml of triethylamine and 10 ml of isopropanol was heated under reflux for 3 hours.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05008267 |
| 出典データセット | uspto-grants-1991_04 |
| ORD ID | ord-2bd4fbbbc3894fdaabbf7c5db9213d68 |
| 出典メモ | uspto-grants-1991_04 |