Acetic Acid → 3-(4-Nitrophenyl)propan-1-amine

HRID 1085291ノート

反応式

HRID 1085291 の反応式
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([CH2:10][CH2:11][C:12]([NH2:14])=O)=[CH:6][CH:5]=1)([O-:3])=[O:2].[BH4-].[Na+].C(O)(=O)C.CO>O1CCOCC1>[N+:1]([C:4]1[CH:5]=[CH:6][C:7]([CH2:10][CH2:11][CH2:12][NH2:14])=[CH:8][CH:9]=1)([O-:3])=[O:2]

参加物

6

反応物 4

HCID 176Acetic AcidHCID 887MethanolHCID 4311764Sodium borohydrideHCID 135960733-(4-Nitrophenyl)propanamide

生成物 1

HCID 144850933-(4-Nitrophenyl)propan-1-amine収率 64.7%

試薬・触媒・溶媒 1

HCID 312751,4-Dioxane溶媒

実験手順

10.0 g of the amide compound and 9.5 g of sodium borohydride were suspended in 250 ml of dioxane, followed by the dropwise addition of 15 ml of acetic acid. The resultant mixture was stirred for 10 hours under reflux. The reaction mixture was added with 10 ml of methanol and then concentrated to dryness. The residue was dissolved in chloroform. The solution thus obtained was washed with water and then concentrated to dryness, thereby obtaining 6.0 g of 3-(4-nitrophenyl)propylamine as an oily substance. This compound was provided for the next reaction without any further purification.

後処理

  1. temperatureunder reflux
  2. concentrationconcentrated to dryness
  3. dissolutionThe residue was dissolved in chloroform
  4. customThe solution thus obtained
  5. washwas washed with water
  6. concentrationconcentrated to dryness

出典と根拠

ORDレコード
ord-717cd8b07f83458bb5b0252cc2cc80e0
出典データセット
uspto-grants-1991_04
特許番号
US05008267

反応ノート

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