Ethanolamine → HCID 20061116、化合物

HRID 1085295ノート

反応式

HRID 1085295 の反応式
Cl[C:2]1[N:7]([CH3:8])[C:6](=[O:9])[N:5]([CH3:10])[C:4](=[O:11])[C:3]=1[CH3:12].[CH2:13]([CH2:15][NH2:16])[OH:14].C(N(CC)CC)C>C(O)(C)C>[OH:14][CH2:13][CH2:15][NH:16][C:2]1[N:7]([CH3:8])[C:6](=[O:9])[N:5]([CH3:10])[C:4](=[O:11])[C:3]=1[CH3:12]

参加物

5

反応物 3

HCID 700EthanolamineHCID 8471TriethylamineHCID 132969876-Chloro-1,3,5-trimethyl-2,4(1H,3H)-pyrimidinedione

生成物 1

HCID 20061116HCID 20061116、化合物

試薬・触媒・溶媒 1

HCID 3776Isopropanol溶媒

実験手順

6-chloro-1,3,5-trimethyl-2,4(1H,3H)-pyrimidinedione (3.4 g) was suspended in 30 ml of isopropanol, and the suspension was added with 1.26 ml of ethanolamine and 3.8 ml of triethylamine and then the resultant mixture was refluxed for 3 hours. The reaction mixture was allowed to stand overnight at room temperature, and thereafter crystals formed were collected by filtration, washed with water and then recrystallized using a water-ethanol solution (1:1, v/v), thereby 2.9 g of 6-(2-hydroxyethylamino)-1,3,5-trimethyl-2,4(1H,3H)-pyrimidinedione being obtained.

後処理

  1. customcrystals formed
  2. filtrationwere collected by filtration
  3. washwashed with water
  4. customrecrystallized

出典と根拠

ORDレコード
ord-2186b3e1ff814175b7218f41cd376278
出典データセット
uspto-grants-1991_04
特許番号
US05008267

反応ノート

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