Ethanolamine → N-(2-hydroxyethyl)-4-thiazolecarboxamide

HRID 1085495ノート

反応式

HRID 1085495 の反応式
[S:1]1[CH:5]=[C:4]([C:6]([O:8]CC)=O)[N:3]=[CH:2]1.[CH2:11]([CH2:13][NH2:14])[OH:12]>>[OH:12][CH2:11][CH2:13][NH:14][C:6]([C:4]1[N:3]=[CH:2][S:1][CH:5]=1)=[O:8]

参加物

3

反応物 2

HCID 700EthanolamineHCID 5003096Ethyl thiazole-4-carboxylate

生成物 1

HCID 20060259N-(2-hydroxyethyl)-4-thiazolecarboxamide

反応条件

温度
100 °C

実験手順

A mixture of ethyl 4-thiazolecarboxylate (24.49 g) and monoethanolamine (28.0 ml) was heated at 100° C. with stirring for 1 hour 20 minutes. After being cooled, the mixture was subjected to column chromatography on silica gel (245 g) and eluted with chloroform. The fractions containing the objective compound were combined and concentrated under reduced pressure to give a light brown oil of N-(2-hydroxyethyl)-4-thiazolecarboxamide (25.93 g).

後処理

  1. temperatureAfter being cooled
  2. washeluted with chloroform
  3. additionThe fractions containing the objective compound
  4. concentrationconcentrated under reduced pressure

出典と根拠

ORDレコード
ord-2464eafe9acc4eecac2f722931d9bdd3
出典データセット
uspto-grants-1991_04
特許番号
US05010093

反応ノート

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