HCID 18633461、化合物 → HCID 15460476、化合物

HRID 1085543ノート

反応式

HRID 1085543 の反応式
[N:1]([CH2:4][C@H:5]1[O:9][C@@H:8]([N:10]2[CH:17]=[C:16]([CH2:18][CH3:19])[C:14](=[O:15])[NH:13][C:11]2=[O:12])[C@@H:7]([F:20])[C@@H:6]1[OH:21])=[N+]=[N-]>C(O)C.[Pd]>[NH2:1][CH2:4][C@H:5]1[O:9][C@@H:8]([N:10]2[CH:17]=[C:16]([CH2:18][CH3:19])[C:14](=[O:15])[NH:13][C:11]2=[O:12])[C@@H:7]([F:20])[C@@H:6]1[OH:21]

参加物

4

反応物 1

HCID 18633461HCID 18633461、化合物

生成物 1

HCID 15460476HCID 15460476、化合物収率 82.1%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 702Ethanol溶媒

実験手順

A solution of 0.4 g of 1-(5-azido-2,5-dideoxy-2-fluoro-β-D-arabinofuranosyl)-5-ethyluracil in 20 ml of ethanol was hydrogenated at room temperature and under atmospheric pressure in the presence of 0.1 g of 10% palladium-on-carbon catalyst for 24 hours. The catalyst was removed by filtration and the filtrate was evaporated. The residue was triturated with diethyl ether and the solid was removed by filtration, washed with ethyl acetate and dried in vacuo to give 0.3 g of 1-(5-amino-2,5-dideoxy-2-fluoro-β-D-arabinofuranosyl)-5-ethyluracil as a white solid.

後処理

  1. customThe catalyst was removed by filtration
  2. customthe filtrate was evaporated
  3. customThe residue was triturated with diethyl ether
  4. customthe solid was removed by filtration
  5. washwashed with ethyl acetate
  6. customdried in vacuo

出典と根拠

ORDレコード
ord-35c0da437f424a28ad8a810e73e32852
出典データセット
uspto-grants-1991_04
特許番号
US05010060

反応ノート

読み込み中…