Water → 4,5-Dichloro-2-(3,4-dichlorophenyl)-1-(ethoxymethyl)pyrrole-3-carbonitrile

HRID 1085600

反応式

HRID 1085600 の反応式
[Cl:1][C:2]1[C:3]([C:16]#[N:17])=[C:4]([C:8]2[CH:13]=[CH:12][C:11]([Cl:14])=[C:10]([Cl:15])[CH:9]=2)[NH:5][C:6]=1[Cl:7].CC(C)([O-])C.[K+].[CH2:24]([O:26][CH2:27]Cl)[CH3:25].O>O1CCCC1>[Cl:1][C:2]1[C:3]([C:16]#[N:17])=[C:4]([C:8]2[CH:13]=[CH:12][C:11]([Cl:14])=[C:10]([Cl:15])[CH:9]=2)[N:5]([CH2:27][O:26][CH2:24][CH3:25])[C:6]=1[Cl:7]

参加物

6

反応物 4

HCID 962WaterHCID 18523Chloromethyl ethyl etherHCID 1835554,5-dichloro-2-(3,4-dichlorophenyl)-1H-pyrrole-3-carbonitrileHCID 23665647Potassium tert-butoxide

生成物 1

HCID 150101404,5-Dichloro-2-(3,4-dichlorophenyl)-1-(ethoxymethyl)pyrrole-3-carbonitrile

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

A sample of 4,5-dichloro-2-(3,4-dichlorophenyl)pyrrole-3-carbonitrile (1.0 g, 0.003 mole) is dissolved in 10 mL of dry tetrahydrofuran. To this solution is added potassium t-butoxide (0.37 g, 0.0033 mole) followed by chloromethyl ethyl ether (0.312 g, 0.0033 mole) The mixture is stirred for about 1 hour at room temperature and then poured into a large volume of water precipitating the product. The white solid is collected and dried to give 1.0 g (91%) with m.p. 128°-130°.

後処理

  1. customThe white solid is collected
  2. customdried
  3. customto give 1.0 g (91%) with m.p. 128°-130°

出典と根拠

ORDレコード
ord-27dc1d58a14842b0af66cb8b5a79a204
出典データセット
uspto-grants-1991_04
特許番号
US05010098

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