Sodium Hydroxide → HCID 11961759、化合物

HRID 1085677ノート

反応式

HRID 1085677 の反応式
O.Br.Br.[CH3:4][N:5]([CH:15]1[CH2:20][CH2:19][NH:18][CH2:17][CH2:16]1)[C:6]1[S:7][C:8]2[CH:14]=[CH:13][CH:12]=[CH:11][C:9]=2[N:10]=1.[OH-].[Na+]>O>[CH3:4][N:5]([CH:15]1[CH2:20][CH2:19][NH:18][CH2:17][CH2:16]1)[C:6]1[S:7][C:8]2[CH:14]=[CH:13][CH:12]=[CH:11][C:9]=2[N:10]=1

参加物

4

反応物 2

HCID 14798Sodium HydroxideHCID 20060646HCID 20060646、化合物

生成物 1

HCID 11961759HCID 11961759、化合物収率 100%

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

A solution of 427 parts of N-methyl-N-(4-piperidinyl)-2-benzothiazolamine dihydrobromide monohydrate in 1500 parts of water was treated with a sodium hydroxide solution 50%. The product was extracted twice with trichloromethane. The combined organic layers were washed with water, dried, filtered and evaporated. The residue was crystallized from 490 parts of 2,2'-oxybispropane. The product was filtered off and dried, yielding 248 parts (100%) of N-methyl-N-(4-piperidinyl)-2-benzothiazolamine; mp. 86.9° C. (68).

後処理

  1. extractionThe product was extracted twice with trichloromethane
  2. washThe combined organic layers were washed with water
  3. customdried
  4. filtrationfiltered
  5. customevaporated
  6. customThe residue was crystallized from 490 parts of 2,2'-oxybispropane
  7. filtrationThe product was filtered off
  8. customdried

出典と根拠

ORDレコード
ord-b9b54207ea314856b9fc54e5d4ed7c64
出典データセット
uspto-grants-1991_04
特許番号
US05010198

反応ノート

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