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4-Methoxynaphthalen-1-ylmethylamine → 4,6-Dichloro-5-(4-methoxy-1-naphthylmethylamino)-3(2H)pyridazinone
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 4-Methoxynaphthalen-1-ylmethylamine | HCID 59139 | — |
| 反応物 | 3,4,5-Trichlor-6-hydroxypyridazin | HCID 11106349 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | 4,6-Dichloro-5-(4-methoxy-1-naphthylmethylamino)-3(2H)pyridazinone | HCID 9884758 | — |
反応手順
A mixture comprising 800 mg of 4,5,6-trichloro-3(2H)pyridazinone, 2.68 g of 4-methoxy-1-naphthylmethylamine and 10 ml of ethanol, was refluxed under stirring for 4 hours. After cooling, precipitated crystals were collected by filtration. Then, the product was dissolved in hot ethyl acetate and treated by silica gel. The filtrate was concentrated, and precipitated crystals were collected by filtration to obtain 330 mg of the above identified compound as colorless crystals having a melting point of from 228° to 231° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05011839 |
| 出典データセット | uspto-grants-1991_04 |
| ORD ID | ord-f83b4264c56b4aef9b9b6fb6f5dcebcc |
| 出典メモ | uspto-grants-1991_04 |