反应详情

A mixture comprising 800 mg of 4,5,6-trichloro-3(2H)pyridazinone, 2.68 g of 4-methoxy-1-naphthylmethylamine and 10 ml of ethanol, was refluxed under stirring for 4 hours. After cooling, precipitated crystals were collected by filtration. Then, the product was dissolved in hot ethyl acetate and treated by silica gel. The filtrate was concentrated, and precipitated crystals were collected by filtration to obtain 330 mg of the above identified compound as colorless crystals having a melting point of from 228° to 231° C.

1. temperaturewas refluxed
2. temperatureAfter cooling
3. customprecipitated crystals
4. filtrationwere collected by filtration
5. dissolutionThen, the product was dissolved in hot ethyl acetate
6. additiontreated by silica gel
7. concentrationThe filtrate was concentrated
8. customprecipitated crystals
9. filtrationwere collected by filtration
10. customto obtain 330 mg of the
11. customof from 228° to 231° C.