Sodium Hydroxide → 5-phenyl-1,3-thiazole-4-carboxylic Acid

HRID 1085823ノート

反応式

HRID 1085823 の反応式
[C:1]1([C:7]2[S:11][CH:10]=[N:9][C:8]=2[C:12]([O:14]CC)=[O:13])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[OH-].[Na+]>>[C:1]1([C:7]2[S:11][CH:10]=[N:9][C:8]=2[C:12]([OH:14])=[O:13])[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

参加物

3

反応物 2

HCID 14798Sodium HydroxideHCID 12300673Ethyl 5-phenylthiazole-4-carboxylate

生成物 1

HCID 9448135-phenyl-1,3-thiazole-4-carboxylic Acid収率 72%

実験手順

The ethyl 5-phenylthiazole-4-carboxylate was hydrolyzed according to known methods with 2N aqueous sodium hydroxide solution at 70° for 30 minutes, whereby, after acidification, there was obtained in 72% yield 5-phenyl-4-thiazolecarboxylic acid which melted at 189°-190° after recrystallization from methanol/diethyl ether.

後処理

  1. customat 70°
  2. customfor 30 minutes

出典と根拠

ORDレコード
ord-1117adfa47b24e9487183e996d0fdc8a
出典データセット
uspto-grants-1991_04
特許番号
US05011849

反応ノート

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